Patch 16.14 · ADC

Kai'Sa against Vayne

Name: Kai'Sa vs Vayne — 44.7% matchup win rate (patch 16.14) | Lanemaster
Creator: Lanemaster
License: https://lanemaster.gg/

Kai'Sa wins 44.7% of the 94 direct matchups against Vayne this patch.

44.7%Kai'Sa

94Games

55.3%Vayne

Best runes against Vayne

Lethal Tempo Precision + Inspiration

45.5%11 games

Lethal Tempo Precision + Inspiration

40.0%10 games

Champion

Kai'Sa
Vayne

Other Kai'Sa matchups

Enemy	Games	Win rate
Ezreal	827	52.8%
Jhin	592	52.2%
Yunara	391	46.0%
Xerath	320	51.3%
Ziggs	308	54.5%
Lucian	291	51.2%
Viktor	266	47.7%
Syndra	246	49.2%

See all champions · See the tier list

Take this data into the client

Lanemaster applies runes, spells and picks automatically in champ select — from the same data on this page.

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Aggregated from Ranked Solo/Duo games at the top of the ladder (Challenger, Grandmaster and Master) on KR, EUW and NA. Updated 2026-07-29 · Patch 16.14.