Patch 16.14 · ADC

Vayne against Kai'Sa

Name: Vayne vs Kai'Sa — 55.3% matchup win rate (patch 16.14) | Lanemaster
Creator: Lanemaster
License: https://lanemaster.gg/

Vayne wins 55.3% of the 94 direct matchups against Kai'Sa this patch.

55.3%Vayne

94Games

44.7%Kai'Sa

Best runes against Kai'Sa

Lethal Tempo Precision + Resolve

40.0%15 games

Press the Attack Precision + Domination

66.7%6 games

Champion

Vayne
Kai'Sa

Other Vayne matchups

Enemy	Games	Win rate
K'Sante	279	58.1%
Ambessa	186	50.5%
Jayce	183	46.4%
Malphite	150	42.0%
Ezreal	145	49.7%
Dr. Mundo	142	54.2%
Gnar	140	52.1%
Mordekaiser	135	53.3%

See all champions · See the tier list

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Lanemaster applies runes, spells and picks automatically in champ select — from the same data on this page.

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Aggregated from Ranked Solo/Duo games at the top of the ladder (Challenger, Grandmaster and Master) on KR, EUW and NA. Updated 2026-07-29 · Patch 16.14.